In their function as cellular recycling plants, proteasomes fulfill a life-sustaining role in all cells -- including cancer cells. When the proteasomes become inhibited, cells suffocate in their own waste. A reversible proteasome inhibition recently discovered at the Technische Universitaet Muenchen may provide the key to more specific anti-cancer drugs and to controlling rejection reactions in transplantations. The international edition of Angewandte Chemie presents their results online ahead of print, featured as a "hot paper."
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